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Extrinsic stabilization of antiviral ACE2-Fc fusion proteins targeting SARS-CoV-2

The angiotensin-converting enzyme 2 (ACE2) is a viral receptor used by sarbecoviruses to infect cells. Fusion proteins comprising extracellular ACE2 domains and the Fc part of immunoglobulins exhibit high virus neutralization efficiency, but the structure and stability of these molecules are poorly...

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Detalles Bibliográficos
Autores principales:	Svilenov, Hristo L., Delhommel, Florent, Siebenmorgen, Till, Rührnößl, Florian, Popowicz, Grzegorz M., Reiter, Alwin, Sattler, Michael, Brockmeyer, Carsten, Buchner, Johannes
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082628/ https://www.ncbi.nlm.nih.gov/pubmed/37031320 http://dx.doi.org/10.1038/s42003-023-04762-w

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