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Shieldin complex assembly kinetics and DNA binding by SHLD3

The Shieldin complex represses end resection at DNA double-strand breaks (DSBs) and thereby serves as a pro-non homologous end joining (NHEJ) factor. The molecular details of the assembly of Shieldin and its recruitment to DSBs are unclear. Shieldin contains two REV7 molecules, which have the rare a...

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Detalles Bibliográficos
Autores principales: Susvirkar, Vivek, Faesen, Alex C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082759/
https://www.ncbi.nlm.nih.gov/pubmed/37031298
http://dx.doi.org/10.1038/s42003-023-04757-7