Multiple sclerosis plasma IgG aggregates induce complement-dependent neuronal apoptosis

Grey matter pathology is central to the progression of multiple sclerosis (MS). We discovered that MS plasma immunoglobulin G (IgG) antibodies, mainly IgG1, form large aggregates (>100 nm) which are retained in the flow-through after binding to Protein A. Utilizing an annexin V live-cell apoptosi...

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Detalles Bibliográficos
Autores principales: Zhou, Wenbo, Graner, Michael, Paucek, Petr, Beseler, Cheryl, Boisen, Matthew, Bubak, Andrew, Asturias, Francisco, George, Woro, Graner, Arin, Ormond, David, Vollmer, Timothy, Alvarez, Enrique, Yu, Xiaoli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082781/
https://www.ncbi.nlm.nih.gov/pubmed/37031195
http://dx.doi.org/10.1038/s41419-023-05783-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082781/
https://www.ncbi.nlm.nih.gov/pubmed/37031195
http://dx.doi.org/10.1038/s41419-023-05783-3

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