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Conformational cycle of human polyamine transporter ATP13A2

Dysregulation of polyamine homeostasis strongly associates with human diseases. ATP13A2, which is mutated in juvenile-onset Parkinson’s disease and autosomal recessive spastic paraplegia 78, is a transporter with a critical role in balancing the polyamine concentration between the lysosome and the c...

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Detalles Bibliográficos
Autores principales: Mu, Jianqiang, Xue, Chenyang, Fu, Lei, Yu, Zongjun, Nie, Minhan, Wu, Mengqi, Chen, Xinmeng, Liu, Kun, Bu, Ruiqian, Huang, Ying, Yang, Baisheng, Han, Jianming, Jiang, Qianru, Chan, Kevin C., Zhou, Ruhong, Li, Huilin, Huang, Ancheng, Wang, Yong, Liu, Zhongmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082790/
https://www.ncbi.nlm.nih.gov/pubmed/37031211
http://dx.doi.org/10.1038/s41467-023-37741-0