Heat-inactivated Factor B inhibits alternative pathway fluid-phase activation and convertase formation on endothelial cell-secreted ultra-large von Willebrand factor strings

Defective regulation of the alternative complement pathway (AP) causes excessive activation and promotes the inflammation and renal injury observed in atypical hemolytic-uremic syndrome (aHUS). The usefulness of heat-inactivated Factor B (HFB) in reducing AP activation was evaluated in: fluid-phase...

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Detalles Bibliográficos
Autores principales: Turner, Nancy A., Moake, Joel L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082794/
https://www.ncbi.nlm.nih.gov/pubmed/37031266
http://dx.doi.org/10.1038/s41598-023-33007-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082794/
https://www.ncbi.nlm.nih.gov/pubmed/37031266
http://dx.doi.org/10.1038/s41598-023-33007-3

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