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The problem of selection bias in studies of pre-mRNA splicing

Here we demonstrate how selection bias in studies of pre-mRNA splicing can inadvertently lead to inaccurate biological conclusions which nevertheless appear statistically robust. We argue that this may be a pervasive problem with potentially significant consequences for the field.

Detalles Bibliográficos
Autores principales: Dwyer, Zachary W., Pleiss, Jeffrey A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082818/
https://www.ncbi.nlm.nih.gov/pubmed/37031238
http://dx.doi.org/10.1038/s41467-023-37650-2