The problem of selection bias in studies of pre-mRNA splicing

Here we demonstrate how selection bias in studies of pre-mRNA splicing can inadvertently lead to inaccurate biological conclusions which nevertheless appear statistically robust. We argue that this may be a pervasive problem with potentially significant consequences for the field.

Detalles Bibliográficos
Autores principales: Dwyer, Zachary W., Pleiss, Jeffrey A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082818/
https://www.ncbi.nlm.nih.gov/pubmed/37031238
http://dx.doi.org/10.1038/s41467-023-37650-2
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author Dwyer, Zachary W.
Pleiss, Jeffrey A.
author_facet Dwyer, Zachary W.
Pleiss, Jeffrey A.
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description Here we demonstrate how selection bias in studies of pre-mRNA splicing can inadvertently lead to inaccurate biological conclusions which nevertheless appear statistically robust. We argue that this may be a pervasive problem with potentially significant consequences for the field.
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spelling pubmed-100828182023-04-10 The problem of selection bias in studies of pre-mRNA splicing Dwyer, Zachary W. Pleiss, Jeffrey A. Nat Commun Comment Here we demonstrate how selection bias in studies of pre-mRNA splicing can inadvertently lead to inaccurate biological conclusions which nevertheless appear statistically robust. We argue that this may be a pervasive problem with potentially significant consequences for the field. Nature Publishing Group UK 2023-04-08 /pmc/articles/PMC10082818/ /pubmed/37031238 http://dx.doi.org/10.1038/s41467-023-37650-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Comment
Dwyer, Zachary W.
Pleiss, Jeffrey A.
The problem of selection bias in studies of pre-mRNA splicing
title The problem of selection bias in studies of pre-mRNA splicing
title_full The problem of selection bias in studies of pre-mRNA splicing
title_fullStr The problem of selection bias in studies of pre-mRNA splicing
title_full_unstemmed The problem of selection bias in studies of pre-mRNA splicing
title_short The problem of selection bias in studies of pre-mRNA splicing
title_sort problem of selection bias in studies of pre-mrna splicing
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082818/
https://www.ncbi.nlm.nih.gov/pubmed/37031238
http://dx.doi.org/10.1038/s41467-023-37650-2
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