Single-component multilayered self-assembling protein nanoparticles presenting glycan-trimmed uncleaved prefusion optimized envelope trimers as HIV-1 vaccine candidates

Uncleaved prefusion-optimized (UFO) design can stabilize diverse HIV-1 envelope glycoproteins (Envs). Single-component, self-assembling protein nanoparticles (1c-SApNP) can display 8 or 20 native-like Env trimers as vaccine candidates. We characterize the biophysical, structural, and antigenic prope...

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Detalles Bibliográficos
Autores principales: Zhang, Yi-Nan, Paynter, Jennifer, Antanasijevic, Aleksandar, Allen, Joel D., Eldad, Mor, Lee, Yi-Zong, Copps, Jeffrey, Newby, Maddy L., He, Linling, Chavez, Deborah, Frost, Pat, Goodroe, Anna, Dutton, John, Lanford, Robert, Chen, Christopher, Wilson, Ian A., Crispin, Max, Ward, Andrew B., Zhu, Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082823/
https://www.ncbi.nlm.nih.gov/pubmed/37031217
http://dx.doi.org/10.1038/s41467-023-37742-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082823/
https://www.ncbi.nlm.nih.gov/pubmed/37031217
http://dx.doi.org/10.1038/s41467-023-37742-z

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