Cargando…

MOZ/ENL complex is a recruiting factor of leukemic AF10 fusion proteins

Changes in the transcriptional machinery cause aberrant self-renewal of non-stem hematopoietic progenitors. AF10 fusions, such as CALM-AF10, are generated via chromosomal translocations, causing malignant leukemia. In this study, we demonstrate that AF10 fusion proteins cause aberrant self-renewal v...

Descripción completa

Detalles Bibliográficos
Autores principales:	Komata, Yosuke, Kanai, Akinori, Maeda, Takahiro, Inaba, Toshiya, Yokoyama, Akihiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082848/ https://www.ncbi.nlm.nih.gov/pubmed/37031220 http://dx.doi.org/10.1038/s41467-023-37712-5

Ejemplares similares

HBO1-MLL interaction promotes AF4/ENL/P-TEFb-mediated leukemogenesis
por: Takahashi, Satoshi, et al.
Publicado: (2021)

HOXA9 promotes MYC-mediated leukemogenesis by maintaining gene expression for multiple anti-apoptotic pathways
por: Miyamoto, Ryo, et al.
Publicado: (2021)

Chemical Inhibition of ENL/AF9 YEATS Domains in Acute Leukemia
por: Garnar-Wortzel, Leopold, et al.
Publicado: (2021)

MOZ is critical for the development of MOZ/MLL fusion–induced leukemia through regulation of Hoxa9/Meis1 expression
por: Katsumoto, Takuo, et al.
Publicado: (2022)

AF4 uses the SL1 components of RNAP1 machinery to initiate MLL fusion- and AEP-dependent transcription
por: Okuda, Hiroshi, et al.
Publicado: (2015)

Role of the MOZ/MLL‐mediated transcriptional activation system for self‐renewal in normal hematopoiesis and leukemogenesis
por: Yokoyama, Akihiko
Publicado: (2021)

MORF and MOZ acetyltransferases target unmethylated CpG islands through the winged helix domain
por: Becht, Dustin C., et al.
Publicado: (2023)

MOZ Regulates the Tbx1 Locus, and Moz Mutation Partially Phenocopies DiGeorge Syndrome
por: Voss, Anne K., et al.
Publicado: (2012)

MLL fusion proteins link transcriptional coactivators to previously active CpG-rich promoters
por: Okuda, Hiroshi, et al.
Publicado: (2014)

Small-molecule inhibitor of AF9/ENL-DOT1L/AF4/AFF4 interactions suppresses malignant gene expression and tumor growth
por: Wu, Fangrui, et al.
Publicado: (2021)

Simultaneous localization of MLL, AF4 and ENL genes in interphase nuclei by 3D-FISH: MLL translocation revisited
por: Gué, Michaël, et al.
Publicado: (2006)

MOZ-TIF2 repression of nuclear receptor-mediated transcription requires multiple domains in MOZ and in the CID domain of TIF2
por: Yin, Hong, et al.
Publicado: (2007)

Discovery, Structure–Activity Relationship and In Vitro Anticancer Activity of Small-Molecule Inhibitors of the Protein–Protein Interactions between AF9/ENL and AF4 or DOT1L
por: Li, Xin, et al.
Publicado: (2023)

Inbound marketing and SEO: insights from the Moz Blog
por: Fishkin, Rand, et al.
Publicado: (2013)

Src family kinase activity drives cytomegalovirus reactivation by recruiting MOZ histone acetyltransferase activity to the viral promoter
por: Dupont, Liane, et al.
Publicado: (2019)

Household Costs of Leprosy Reactions (ENL) in Rural India
por: Chandler, David J., et al.
Publicado: (2015)

Transcription control by the ENL YEATS domain in acute leukemia
por: Erb, Michael A., et al.
Publicado: (2017)

Expression of the MOZ-TIF2 oncoprotein in mice represses senescence
por: Largeot, Anne, et al.
Publicado: (2016)

ENL links histone acetylation to oncogenic gene expression in AML
por: Wan, Liling, et al.
Publicado: (2017)

Myeloid transformation by MLL-ENL depends strictly on C/EBP
por: Wesolowski, Radoslaw, et al.
Publicado: (2020)

RNA Polymerase II-Dependent Transcription Initiated by Selectivity Factor 1: A Central Mechanism Used by MLL Fusion Proteins in Leukemic Transformation
por: Yokoyama, Akihiko
Publicado: (2019)

Neutrophil NETworking in ENL: Potential as a Putative Biomarker: Future Insights
por: Sahu, Smrity, et al.
Publicado: (2021)

Bivalent complexes of PRC1 with orthologs of BRD4 and MOZ/MORF target developmental genes in Drosophila
por: Kang, Hyuckjoon, et al.
Publicado: (2017)

The MOZ-BRPF1 acetyltransferase complex in epigenetic crosstalk linked to gene regulation, development, and human diseases
por: Viita, Tiina, et al.
Publicado: (2023)

Does the enterolactone (ENL) affect fatty acid transporters and lipid metabolism in liver?
por: Drygalski, Krzysztof, et al.
Publicado: (2017)

Tet1 is not required for myeloid leukemogenesis by MLL-ENL in novel mouse models
por: Ono, Ryoichi, et al.
Publicado: (2021)

ENL initiates multivalent phase separation of the super elongation complex (SEC) in controlling rapid transcriptional activation
por: Guo, Chenghao, et al.
Publicado: (2020)

MOZ Forms an Autoregulatory Feedback Loop with miR-223 in AML and Monocyte/Macrophage Development
por: Jiang, Ming, et al.
Publicado: (2018)

Zoledronic acid inhibits the growth of leukemic MLL-AF9 transformed hematopoietic cells
por: Chiarella, Emanuela, et al.
Publicado: (2020)

Immunoediting is not a primary transformation event in a murine model of MLL-ENL AML
por: Dudenhöffer-Pfeifer, Monika, et al.
Publicado: (2018)

Concerto grosso no. 1 ; Quasi una sonata ; Moz-Art á la Haydn ; A Paganini
por: Schnittke, Alfred, 1934-
Publicado: (1990)

A Novel Inducible Mouse Model of MLL-ENL-driven Mixed-lineage Acute Leukemia
por: Stavropoulou, Vaia, et al.
Publicado: (2018)

The role of the PZP domain of AF10 in acute leukemia driven by AF10 translocations
por: Klein, Brianna J., et al.
Publicado: (2021)

Evaluation of the Mozambique Antiretroviral Therapy (MozART) database as an antiretroviral therapy patient surveillance system, 2017-2018
por: Fataha, Neusa Vanessa Fernandes Abdul, et al.
Publicado: (2022)

The human leukemic oncogene MLL-AF4 promotes hyperplastic growth of hematopoietic tissues in Drosophila larvae
por: Johannessen, Julie A., et al.
Publicado: (2023)

Hematopoietic Stem Cell (HSC)-Independent Progenitors Are Susceptible to Mll-Af9-Induced Leukemic Transformation
por: Barone, Cristiana, et al.
Publicado: (2023)

Small-Molecule Inhibition of the Acyl-Lysine Reader ENL as a Strategy against Acute Myeloid Leukemia
por: Liu, Yiman, et al.
Publicado: (2022)

Structural and functional analysis of the DOT1L–AF10 complex reveals mechanistic insights into MLL-AF10-associated leukemogenesis
por: Zhang, Heng, et al.
Publicado: (2018)

MOZ-Mediated Repression of p16(INK)(4)(a) Is Critical for the Self-Renewal of Neural and Hematopoietic Stem Cells
por: Perez-Campo, Flor M, et al.
Publicado: (2014)

Guía pedagógica en Enfoque Neurolingüístico (ENL) para la enseñanza del español como lengua extranjera
por: Benudiz, Gladys, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_5h0a9sddqhirb0b2ff9l6h19d5