C9orf72 poly-GA proteins impair neuromuscular transmission

Amyotrophic lateral sclerosis (ALS) is a devastating motoneuron disease, in which lower motoneurons lose control of skeletal muscles. Degeneration of neuromuscular junctions (NMJs) occurs at the initial stage of ALS. Dipeptide repeat proteins (DPRs) from G4C2 repeat-associated non-ATG (RAN) translat...

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Detalles Bibliográficos
Autores principales: Tu, Wen-Yo, Xu, Wentao, Zhang, Jianmin, Qi, Shuyuan, Bai, Lei, Shen, Chengyong, Zhang, Kejing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Science Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10083233/
https://www.ncbi.nlm.nih.gov/pubmed/36799225
http://dx.doi.org/10.24272/j.issn.2095-8137.2022.356

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10083233/
https://www.ncbi.nlm.nih.gov/pubmed/36799225
http://dx.doi.org/10.24272/j.issn.2095-8137.2022.356

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