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A general mechanism for transcription bubble nucleation in bacteria

Bacterial transcription initiation requires σ factors for nucleation of the transcription bubble. The canonical housekeeping σ factor, σ(70), nucleates DNA melting via recognition of conserved bases of the promoter −10 motif, which are unstacked and captured in pockets of σ(70). By contrast, the mec...

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Detalles Bibliográficos
Autores principales: Mueller, Andreas U., Chen, James, Wu, Mengyu, Chiu, Courtney, Nixon, B. Tracy, Campbell, Elizabeth A., Darst, Seth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10083551/
https://www.ncbi.nlm.nih.gov/pubmed/36972428
http://dx.doi.org/10.1073/pnas.2220874120