A DNA damage–induced phosphorylation circuit enhances Mec1(ATR) Ddc2(ATRIP) recruitment to Replication Protein A

The cell cycle checkpoint kinase Mec1(ATR) and its integral partner Ddc2(ATRIP) are vital for the DNA damage and replication stress response. Mec1–Ddc2 “senses” single-stranded DNA (ssDNA) by being recruited to the ssDNA binding Replication Protein A (RPA) via Ddc2. In this study, we show that a DNA...

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Detalles Bibliográficos
Autores principales: Yates, Luke A., Tannous, Elias A., Morgan, R. Marc, Burgers, Peter M., Zhang, Xiaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10083555/
https://www.ncbi.nlm.nih.gov/pubmed/36996117
http://dx.doi.org/10.1073/pnas.2300150120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10083555/
https://www.ncbi.nlm.nih.gov/pubmed/36996117
http://dx.doi.org/10.1073/pnas.2300150120

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