HPV16 E6 induces chromosomal instability due to polar chromosomes caused by E6AP-dependent degradation of the mitotic kinesin CENP-E

Chromosome segregation during mitosis is highly regulated to ensure production of genetically identical progeny. Recurrent mitotic errors cause chromosomal instability (CIN), a hallmark of tumors. The E6 and E7 oncoproteins of high-risk human papillomavirus (HPV), which causes cervical, anal, and he...

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Detalles Bibliográficos
Autores principales: Cosper, Pippa F., Hrycyniak, Laura C. F., Paracha, Maha, Lee, Denis L., Wan, Jun, Jones, Kathryn, Bice, Sophie A., Nickel, Kwangok, Mallick, Samyukta, Taylor, Alison M., Kimple, Randall J., Lambert, Paul F., Weaver, Beth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10083562/
https://www.ncbi.nlm.nih.gov/pubmed/36989302
http://dx.doi.org/10.1073/pnas.2216700120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10083562/
https://www.ncbi.nlm.nih.gov/pubmed/36989302
http://dx.doi.org/10.1073/pnas.2216700120

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