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Identification of a broadly conserved family of enzymes that hydrolyze (p)ppApp

Bacteria produce a variety of nucleotide second messengers to adapt to their surroundings. Although chemically similar, the nucleotides guanosine penta- and tetraphosphate [(p)ppGpp] and adenosine penta- and tetraphosphate [(p)ppApp] have distinct functions in bacteria. (p)ppGpp mediates survival un...

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Detalles Bibliográficos
Autores principales: Ahmad, Shehryar, Gordon, Isis J., Tsang, Kara K., Alexei, Andrea G., Sychantha, David, Colautti, Jake, Trilesky, Sarah L., Kim, Youngchang, Wang, Boyuan, Whitney, John C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10083569/
https://www.ncbi.nlm.nih.gov/pubmed/36989297
http://dx.doi.org/10.1073/pnas.2213771120