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Acute phosphatidylinositol 4,5 bisphosphate depletion destabilizes sarcolemmal expression of cardiac L-type Ca(2+) channel Ca(V)1.2
Ca(V)1.2 channels are critical players in cardiac excitation–contraction coupling, yet we do not understand how they are affected by an important therapeutic target of heart failure drugs and regulator of blood pressure, angiotensin II. Signaling through G(q)-coupled AT1 receptors, angiotensin II tr...
Autores principales: | Voelker, Taylor L., del Villar, Silvia G., Westhoff, Maartje, Costa, Alexandre D., Coleman, Andrea M., Hell, Johannes W., Horne, Mary C., Dickson, Eamonn J., Dixon, Rose E. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10083594/ https://www.ncbi.nlm.nih.gov/pubmed/36976770 http://dx.doi.org/10.1073/pnas.2221242120 |
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