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BRCA2 chaperones RAD51 to single molecules of RPA-coated ssDNA

Mutations in the breast cancer susceptibility gene, BRCA2, greatly increase an individual’s lifetime risk of developing breast and ovarian cancers. BRCA2 suppresses tumor formation by potentiating DNA repair via homologous recombination. Central to recombination is the assembly of a RAD51 nucleoprot...

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Detalles Bibliográficos
Autores principales: Bell, Jason C., Dombrowski, Christopher C., Plank, Jody L., Jensen, Ryan B., Kowalczykowski, Stephen C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10083600/
https://www.ncbi.nlm.nih.gov/pubmed/36976771
http://dx.doi.org/10.1073/pnas.2221971120