Glucocorticoid activation by HSD11B1 limits T cell-driven interferon signaling and response to PD-1 blockade in melanoma

BACKGROUND: Immune responses against tumors are subject to negative feedback regulation. Immune checkpoint inhibitors (ICIs) blocking Programmed cell death protein 1 (PD-1), a receptor expressed on T cells, or its ligand PD-L1 have significantly improved the treatment of cancer, in particular malign...

Descripción completa

Detalles Bibliográficos
Autores principales: Martins Nascentes Melo, Luiza, Herrera-Rios, Dayana, Hinze, Daniel, Löffek, Stefanie, Oezel, Irem, Turiello, Roberta, Klein, Juliane, Leonardelli, Sonia, Westedt, Isa-Vanessa, Al-Matary, Yahya, Egea-Rodriguez, Sara, Brenzel, Alexandra, Bau, Maja, Sucker, Antje, Hadaschik, Eva, Wirsdörfer, Florian, Hanenberg, Helmut, Uhlenbrock, Niklas, Rauh, Daniel, Poźniak, Joanna, Rambow, Florian, Marine, Jean-Christophe, Effern, Maike, Glodde, Nicole, Schadendorf, Dirk, Jablonska, Jadwiga, Hölzel, Michael, Helfrich, Iris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10083881/
https://www.ncbi.nlm.nih.gov/pubmed/37028818
http://dx.doi.org/10.1136/jitc-2021-004150

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10083881/
https://www.ncbi.nlm.nih.gov/pubmed/37028818
http://dx.doi.org/10.1136/jitc-2021-004150

Ejemplares similares