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High plasma levels of betaine, a trimethylamine N‐Oxide‐related metabolite, are associated with the severity of cirrhosis

BACKGROUND AND AIMS: The gut microbiome‐related metabolites betaine and trimethylamine N‐oxide (TMAO) affect major health issues. In cirrhosis, betaine metabolism may be diminished because of impaired hepatic betaine homocysteine methyltransferase activity, whereas TMAO generation from trimethylamin...

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Detalles Bibliográficos
Autores principales: van den Berg, Eline H., Flores‐Guerrero, Jose L., Garcia, Erwin, Connelly, Margery A., de Meijer, Vincent E., Bakker, Stephan J. L., Blokzijl, Hans, Dullaart, Robin P. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10084422/
https://www.ncbi.nlm.nih.gov/pubmed/35585781
http://dx.doi.org/10.1111/liv.15310