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Genome-wide association testing in malaria studies in the presence of overdominance
BACKGROUND: In human genetics, heterozygote advantage (heterosis) has been detected in studies that focused on specific genes but not in genome-wide association studies (GWAS). For example, heterosis is believed to confer resistance to certain strains of malaria in patients heterozygous for the sick...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10084622/ https://www.ncbi.nlm.nih.gov/pubmed/37038187 http://dx.doi.org/10.1186/s12936-023-04533-2 |