Cellular senescence and disrupted proteostasis induced by myotube atrophy are prevented with low-dose metformin and leucine cocktail

Aging coincides with the accumulation of senescent cells within skeletal muscle that produce inflammatory products, known as the senescence-associated secretory phenotype, but the relationship of senescent cells to muscle atrophy is unclear. Previously, we found that a metformin + leucine (MET+LEU)...

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Detalles Bibliográficos
Autores principales: Petrocelli, Jonathan J., de Hart, Naomi M.M.P., Lang, Marisa J., Yee, Elena M., Ferrara, Patrick J., Fix, Dennis K., Chaix, Amandine, Funai, Katsuhiko, Drummond, Micah J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10085594/
https://www.ncbi.nlm.nih.gov/pubmed/36947713
http://dx.doi.org/10.18632/aging.204600

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10085594/
https://www.ncbi.nlm.nih.gov/pubmed/36947713
http://dx.doi.org/10.18632/aging.204600

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