Proximal binding of dCas9 at a DNA double strand break stimulates homology-directed repair as a local inhibitor of classical non-homologous end joining

In CRISPR/Cas9 genome editing, the tight and persistent target binding of Cas9 provides an opportunity for efficient genetic and epigenetic modification on genome. In particular, technologies based on catalytically dead Cas9 (dCas9) have been developed to enable genomic regulation and live imaging i...

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Detalles Bibliográficos
Autores principales: Feng, Yi-Li, Liu, Si-Cheng, Chen, Ruo-Dan, Sun, Xiu-Na, Xiao, Jing-Jing, Xiang, Ji-Feng, Xie, An-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10085678/
https://www.ncbi.nlm.nih.gov/pubmed/36864759
http://dx.doi.org/10.1093/nar/gkad116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10085678/
https://www.ncbi.nlm.nih.gov/pubmed/36864759
http://dx.doi.org/10.1093/nar/gkad116

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