Filament assembly underpins the double-stranded DNA specificity of AIM2-like receptors

Upon sensing cytosolic- and/or viral double-stranded (ds)DNA, absent-in-melanoma-2 (AIM2)-like-receptors (ALRs) assemble into filamentous signaling platforms to initiate inflammatory responses. The versatile yet critical roles of ALRs in host innate defense are increasingly appreciated; however, the...

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Detalles Bibliográficos
Autores principales: Garg, Archit, Stallings, Christina M, Sohn, Jungsan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10085679/
https://www.ncbi.nlm.nih.gov/pubmed/36864667
http://dx.doi.org/10.1093/nar/gkad090

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10085679/
https://www.ncbi.nlm.nih.gov/pubmed/36864667
http://dx.doi.org/10.1093/nar/gkad090

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