Internal RNA 2′O-methylation in the HIV-1 genome counteracts ISG20 nuclease-mediated antiviral effect

RNA 2′O-methylation is a ‘self’ epitranscriptomic modification allowing discrimination between host and pathogen. Indeed, human immunodeficiency virus 1 (HIV-1) induces 2′O-methylation of its genome by recruiting the cellular FTSJ3 methyltransferase, thereby impairing detection by RIG-like receptors...

Descripción completa

Detalles Bibliográficos
Autores principales: El Kazzi, Priscila, Rabah, Nadia, Chamontin, Célia, Poulain, Lina, Ferron, François, Debart, Françoise, Canard, Bruno, Missé, Dorothée, Coutard, Bruno, Nisole, Sébastien, Decroly, Etienne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
NAR Breakthrough Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10085690/
https://www.ncbi.nlm.nih.gov/pubmed/36354007
http://dx.doi.org/10.1093/nar/gkac996

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10085690/
https://www.ncbi.nlm.nih.gov/pubmed/36354007
http://dx.doi.org/10.1093/nar/gkac996

Ejemplares similares