The mismatch repair endonuclease MutLα tethers duplex regions of DNA together and relieves DNA torsional tension

In eukaryotic mismatch repair, MutS homologs recognize mismatches and recruit the MutLα endonuclease which introduces a nick in the newly replicated, error-containing DNA strand. The nick occurs in response to the mismatch, but at a site up to several hundred base pairs away. The MutLα nick promotes...

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Detalles Bibliográficos
Autores principales: Witte, Scott J, Rosa, Isabella M, Collingwood, Bryce W, Piscitelli, Jonathan M, Manhart, Carol M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10085691/
https://www.ncbi.nlm.nih.gov/pubmed/36840719
http://dx.doi.org/10.1093/nar/gkad096

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10085691/
https://www.ncbi.nlm.nih.gov/pubmed/36840719
http://dx.doi.org/10.1093/nar/gkad096

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