Sarecycline inhibits protein translation in Cutibacterium acnes 70S ribosome using a two-site mechanism

Acne vulgaris is a chronic disfiguring skin disease affecting ∼1 billion people worldwide, often having persistent negative effects on physical and mental health. The Gram-positive anaerobe, Cutibacterium acnes is implicated in acne pathogenesis and is, therefore, a main target for antibiotic-based...

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Detalles Bibliográficos
Autores principales: Lomakin, Ivan B, Devarkar, Swapnil C, Patel, Shivali, Grada, Ayman, Bunick, Christopher G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10085706/
https://www.ncbi.nlm.nih.gov/pubmed/36864821
http://dx.doi.org/10.1093/nar/gkad103

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10085706/
https://www.ncbi.nlm.nih.gov/pubmed/36864821
http://dx.doi.org/10.1093/nar/gkad103

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