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Chemistry, structure and function of approved oligonucleotide therapeutics

Eighteen nucleic acid therapeutics have been approved for treatment of various diseases in the last 25 years. Their modes of action include antisense oligonucleotides (ASOs), splice-switching oligonucleotides (SSOs), RNA interference (RNAi) and an RNA aptamer against a protein. Among the diseases ta...

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Detalles Bibliográficos
Autores principales: Egli, Martin, Manoharan, Muthiah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10085713/
https://www.ncbi.nlm.nih.gov/pubmed/36881759
http://dx.doi.org/10.1093/nar/gkad067