Evaluation of the Potential for Cytochrome P450 and Transporter-Mediated Drug-Drug Interactions for Cilofexor, a Selective Nonsteroidal Farnesoid X Receptor (FXR) Agonist

BACKGROUND AND OBJECTIVE: Cilofexor is a selective farnesoid X receptor (FXR) agonist in development for the treatment of nonalcoholic steatohepatitis and primary sclerosing cholangitis. Our objective was to evaluate potential drug-drug interactions of cilofexor as a victim and as a perpetrator. MET...

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Detalles Bibliográficos
Autores principales: Younis, Islam, Weber, Elijah, Nelson, Cara, Kirby, Brian J., Shen, Gong, Xiao, Deqing, Watkins, Timothy R., Othman, Ahmed A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10085937/
https://www.ncbi.nlm.nih.gov/pubmed/36906733
http://dx.doi.org/10.1007/s40262-023-01214-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10085937/
https://www.ncbi.nlm.nih.gov/pubmed/36906733
http://dx.doi.org/10.1007/s40262-023-01214-w

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