Restoring bone marrow niche function rejuvenates aged hematopoietic stem cells by reactivating the DNA Damage Response

Aging associated defects within stem cell-supportive niches contribute towards age-related decline in stem cell activity. However, mechanisms underlying age-related niche defects, and whether restoring niche function can improve stem cell fitness, remain unclear. Here, we sought to determine whether...

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Detalles Bibliográficos
Autores principales: Ramalingam, Pradeep, Gutkin, Michael C., Poulos, Michael G., Tillery, Taylor, Doughty, Chelsea, Winiarski, Agatha, Freire, Ana G., Rafii, Shahin, Redmond, David, Butler, Jason M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086043/
https://www.ncbi.nlm.nih.gov/pubmed/37037837
http://dx.doi.org/10.1038/s41467-023-37783-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086043/
https://www.ncbi.nlm.nih.gov/pubmed/37037837
http://dx.doi.org/10.1038/s41467-023-37783-4

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