Aggrelyte‐2 promotes protein solubility and decreases lens stiffness through lysine acetylation and disulfide reduction: Implications for treating presbyopia

Aging proteins in the lens become increasingly aggregated and insoluble, contributing to presbyopia. In this study, we investigated the ability of aggrelyte‐2 (N,S‐diacetyl‐L‐cysteine methyl ester) to reverse the water insolubility of aged human lens proteins and to decrease stiffness in cultured hu...

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Detalles Bibliográficos
Autores principales: Panja, Sudipta, Nahomi, Rooban B., Rankenberg, Johanna, Michel, Cole R., Gaikwad, Hanmant, Nam, Mi‐Hyun, Nagaraj, Ram H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086532/
https://www.ncbi.nlm.nih.gov/pubmed/36823285
http://dx.doi.org/10.1111/acel.13797

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086532/
https://www.ncbi.nlm.nih.gov/pubmed/36823285
http://dx.doi.org/10.1111/acel.13797

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