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Aggrelyte‐2 promotes protein solubility and decreases lens stiffness through lysine acetylation and disulfide reduction: Implications for treating presbyopia
Aging proteins in the lens become increasingly aggregated and insoluble, contributing to presbyopia. In this study, we investigated the ability of aggrelyte‐2 (N,S‐diacetyl‐L‐cysteine methyl ester) to reverse the water insolubility of aged human lens proteins and to decrease stiffness in cultured hu...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086532/ https://www.ncbi.nlm.nih.gov/pubmed/36823285 http://dx.doi.org/10.1111/acel.13797 |