Timosaponin AIII promotes non-small-cell lung cancer ferroptosis through targeting and facilitating HSP90 mediated GPX4 ubiquitination and degradation

Timosaponin AIII (Tim-AIII), a steroid saponin, exhibits strong anticancer activity in a variety of cancers, especially breast cancer and liver cancer. However, the underlying mechanism of the effects of Tim-AIII-mediated anti-lung cancer effects remain obscure. In this study, we showed that Tim-AII...

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Detalles Bibliográficos
Autores principales: Zhou, Cong, Yu, Ting, Zhu, Rui, Lu, Junjie, Ouyang, Xiaohu, Zhang, Zili, Chen, Qianyun, Li, Junyi, Cui, Jing, Jiang, Feng, Jin, Kim Yun, Sarapultsev, Alexey, Li, Fangfei, Zhang, Ge, Luo, Shanshan, Hu, Desheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086754/
https://www.ncbi.nlm.nih.gov/pubmed/37056925
http://dx.doi.org/10.7150/ijbs.77979

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086754/
https://www.ncbi.nlm.nih.gov/pubmed/37056925
http://dx.doi.org/10.7150/ijbs.77979

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