Cargando…

Switching positions: Assessing the dynamics of conjugational heterogeneity in antibody–drug conjugates using CE‐SDS

Antibody–drug conjugates (ADCs) are a prospective class of new oncology therapeutics with the ability to deliver a cytotoxic drug to a targeted location. The concept appears simple, but ADCs are highly complex due to their intrinsic heterogeneity. Randomly conjugated ADCs, for instance, are composed...

Descripción completa

Detalles Bibliográficos
Autores principales:	van den Berg, Eline B. A., Hendriks, Jaap C. W., Elsinga, Everdine W., Eggink, Mark, Dirksen, Eef H. C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	General, Ce & Cec
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086850/ https://www.ncbi.nlm.nih.gov/pubmed/35907250 http://dx.doi.org/10.1002/elps.202200140

Ejemplares similares

Enantioselective CE–MS analysis of ketamine metabolites in urine
por: Sandbaumhüter, Friederike A., et al.
Publicado: (2022)

Methionine oxidation of proteins analyzed by affinity capillary electrophoresis in presence of silver(I) and gold(III) ions
por: Hutanu, Andrei, et al.
Publicado: (2021)

Four‐step approach to efficiently develop capillary gel electrophoresis methods for viral vaccine protein analysis
por: Geurink, Lars, et al.
Publicado: (2020)

Past, present, and future developments in enantioselective analysis using capillary electromigration techniques
por: de Koster, Nicky, et al.
Publicado: (2020)

Stereoselective methadone disposition after administration of racemic methadone to anesthetized Shetland ponies assessed by capillary electrophoresis
por: Sandbaumhüter, Friederike A., et al.
Publicado: (2021)

Online hyphenation of size‐exclusion chromatography and gas‐phase electrophoresis facilitates the characterization of protein aggregates
por: Weiss, Victor U., et al.
Publicado: (2021)

Dynamic computer simulations of electrophoresis: 2010–2020
por: Thormann, Wolfgang, et al.
Publicado: (2021)

The effect of pH adjusted electrolytes on capillary isoelectric focusing assessed by high‐resolution dynamic computer simulation
por: Takácsi‐Nagy, Anna, et al.
Publicado: (2021)

Rapid determination of NSAIDs by capillary and microchip electrophoresis with capacitively coupled contactless conductivity detection in wastewater
por: Alatawi, Hanan, et al.
Publicado: (2022)

Separation of unsaturated C18 fatty acids using perfluorinated‐micellar electrokinetic chromatography: I. Optimization and separation process
por: Ta, Hai Yen, et al.
Publicado: (2022)

Method development for quantitative monitoring of monoclonal antibodies in upstream cell‐culture process samples with limited sample preparation – An evaluation of various capillary coatings
por: van der Burg, Debbie, et al.
Publicado: (2022)

CE–MS for anionic metabolic profiling: An overview of methodological developments
por: van Mever, Marlien, et al.
Publicado: (2019)

Chiral separation of cathinone derivatives using β‐cyclodextrin‐assisted capillary electrophoresis–Comparison of four different β‐cyclodextrin derivatives used as chiral selectors
por: Hägele, Johannes S., et al.
Publicado: (2019)

Assessing the suitability of capillary electrophoresis‐mass spectrometry for biomarker discovery in plasma‐based metabolomics
por: Zhang, Wei, et al.
Publicado: (2019)

Patient Perspective, Complexities, and Challenges in Managed Care
por: Jan, Saira
Publicado: (2010)

Atrial Fibrillation and Managed Care: Current Approaches and Future Directions for Long-Term Therapy
por: Sanoski, Cynthia A., et al.
Publicado: (2009)

Choline: The Underconsumed and Underappreciated Essential Nutrient
por: Wallace, Taylor C., et al.
Publicado: (2018)

Switch from oral anticoagulants to parenteral heparin in SARS-CoV-2 hospitalized patients: comment
por: Allione, Attilio, et al.
Publicado: (2020)

Switch from oral anticoagulants to parenteral heparin in SARS-CoV-2 hospitalized patients: comment
por: Roncon, Loris, et al.
Publicado: (2020)

Eating disorder symptomatology and substance use disorders: Prevalence and shared risk in a population based twin sample
por: Baker, Jessica H, et al.
Publicado: (2010)

Use of ß-blocker therapy to prevent primary bleeding of esophageal varices
por: Tursi, Tammy
Publicado: (2010)

Mediterranean Diet and Prevention of Chronic Diseases
por: Romagnolo, Donato F., et al.
Publicado: (2017)

What Is the Evidence Base for a Potassium Requirement?
por: Weaver, Connie M., et al.
Publicado: (2018)

Optimizing Treatment and Improving Outcomes for Patients With Acute Myeloid Leukemia: A Guide for Advanced Practitioners
Publicado: (2019)

Advances in HER2-Positive Breast Cancer: Novel Therapies and Adverse Event Management
Publicado: (2019)

Pulmonary embolism and screening for concomitant proximal deep vein thrombosis in noncritically ill hospitalized patients with coronavirus disease 2019
por: Lazzeri, Chiara, et al.
Publicado: (2020)

Derivation of age-adjusted LACE index thresholds in the prediction of mortality and frequent hospital readmissions in adults
por: Fry, Christopher Henry, et al.
Publicado: (2020)

The Role of Advanced Practitioners in Optimizing Clinical Management and Support of Patients With Cytokine Release Syndrome From CAR T-Cell Therapy
Publicado: (2019)

Advances in Oral Oncolytic Agents for Breast Cancer and Recommendations for Promoting Adherence
Publicado: (2020)

COVID-19: counter-intuitive data on smoking prevalence and therapeutic implications for nicotine
por: Polosa, Riccardo, et al.
Publicado: (2020)

High-dose steroids for the treatment of severe COVID-19: a new therapeutic tool?
por: Cameli, Paolo, et al.
Publicado: (2021)

Body mass index (BMI) influence on Cetuximab-induced antibody-dependent cellular cytotoxicity in advanced colon cancer
por: Tralongo, Antonino Carmelo, et al.
Publicado: (2022)

Organ Transplantation Outcomes of Deceased Organ Donors in Organ Procurement Organization-Based Recovery Facilities Versus Acute-Care Hospitals
por: Vail, Emily A., et al.
Publicado: (2023)

Deceased Organ Donor Management and Organ Distribution From Organ Procurement Organization-Based Recovery Facilities Versus Acute-Care Hospitals
por: Vail, Emily A., et al.
Publicado: (2023)

Physical properties of steroid conjugates
por: Bernstein, Seymour, et al.
Publicado: (1968)

A high precision method for length-based separation of carbon nanotubes using bio-conjugation, SDS-PAGE and silver staining
por: Borzooeian, Zahra, et al.
Publicado: (2018)

Real-time observation of conformational switching in single conjugated polymer chains
por: Tenopala-Carmona, Francisco, et al.
Publicado: (2018)

Time reversal of Berry's topological phase by optical phase conjugation
por: Tompkin, W R, et al.
Publicado: (1988)

CE Separation and ICP-MS Detection of Gold Nanoparticles and Their Protein Conjugates
por: Legat, Joanna, et al.
Publicado: (2017)

CeO(2)-Azacrown Conjugate as a Nanoplatform for Combined Radiopharmaceuticals
por: Khabirova, Sofia, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_3u9ckb6kme2enta1tfmmf205b5