A mechanistic PK/PD model to enable dose selection of the potent anti‐tryptase antibody (MTPS9579A) in patients with moderate‐to‐severe asthma

Tryptase, a protease implicated in asthma pathology, is secreted from mast cells upon activation during an inflammatory allergic response. MTPS9579A is a novel monoclonal antibody that inhibits tryptase activity by irreversibly dissociating the active tetramer into inactive monomers. This study asse...

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Detalles Bibliográficos
Autores principales: Rymut, Sharon M., Henderson, Lindsay M., Poon, Victor, Staton, Tracy L., Cai, Fang, Sukumaran, Siddharth, Rhee, Horace, Owen, Ryan, Ramanujan, Saroja, Yoshida, Kenta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10087065/
https://www.ncbi.nlm.nih.gov/pubmed/36755366
http://dx.doi.org/10.1111/cts.13483

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10087065/
https://www.ncbi.nlm.nih.gov/pubmed/36755366
http://dx.doi.org/10.1111/cts.13483

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