Correlations between preclinical BJAB assay ranking of antisense drugs and clinical trial adverse events

This analysis sought to assess the clinical predictivity of an in vitro assay which utilized the human B‐lymphoma BJAB cell line, for identification of antisense oligonucleotides (ASOs) with the potential to elicit innate immune activation in humans. Adverse events (AEs) from clinical trial data wer...

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Detalles Bibliográficos
Autores principales: Partridge, Wesley, Burel, Sebastien A., Ferng, Annie, Xia, Shuting, Kwoh, T. Jesse, Henry, Scott P., Baker, Brenda F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10087069/
https://www.ncbi.nlm.nih.gov/pubmed/36631935
http://dx.doi.org/10.1111/cts.13476

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10087069/
https://www.ncbi.nlm.nih.gov/pubmed/36631935
http://dx.doi.org/10.1111/cts.13476

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