PK/PD analysis of trazodone and gabapentin in neuropathic pain rodent models: Translational PK‐PD modeling from nonclinical to clinical development

A pharmacokinetic/pharmacodynamic (PK/PD) model was developed to describe the time course of writhings after intraperitoneal injection of acetic acid in mice. The model was applied to investigate the antinociceptive effect of trazodone and gabapentin alone and in combination. Writhings time course w...

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Detalles Bibliográficos
Autores principales: Oggianu, Laura, Garrone, Beatrice, Fiorentini, Francesco, Del Bene, Francesca, Rosignoli, Maria Teresa, Di Giorgio, Francesco Paolo, Kaminski, Rafal Marian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10087074/
https://www.ncbi.nlm.nih.gov/pubmed/36785922
http://dx.doi.org/10.1111/cts.13472

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10087074/
https://www.ncbi.nlm.nih.gov/pubmed/36785922
http://dx.doi.org/10.1111/cts.13472

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