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Structural studies offer a framework for understanding the role of properdin in the alternative pathway and beyond

Structures of alternative pathway proteins have offered a comprehensive structural basis for understanding the molecular mechanisms governing activation and regulation of the amplification pathway of the complement cascade. Although properdin (FP) is required in vivo to sustain a functional alternat...

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Detalles Bibliográficos
Autores principales: Pedersen, Dennis Vestergaard, Lorentzen, Josefine, Andersen, Gregers Rom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10087229/
https://www.ncbi.nlm.nih.gov/pubmed/36097870
http://dx.doi.org/10.1111/imr.13129