Influence of Renal Function on Phosphoramide Mustard Exposure: A Nonlinear Mixed‐Effects Analysis

Phosphoramide mustard (PM) is the final cytotoxic metabolite formed from the parent compound cyclophosphamide through a complex metabolic pathway, primarily through hepatic metabolism. Little is known about the effect of renal elimination on the disposition of PM. We evaluated the effect of renal fu...

Descripción completa

Detalles Bibliográficos
Autores principales: Jaber, Mutaz M., Takahashi, Takuto, Kirstein, Mark N., Al‐Kofahi, Mahmoud, Jacobson, Pamala A., Brundage, Richard C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Pharmacokinetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10087276/
https://www.ncbi.nlm.nih.gov/pubmed/36063026
http://dx.doi.org/10.1002/jcph.2144

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10087276/
https://www.ncbi.nlm.nih.gov/pubmed/36063026
http://dx.doi.org/10.1002/jcph.2144

Ejemplares similares