Extracellular vesicles  produced by bone marrow mesenchymal stem cells overexpressing programmed death‐ligand 1 ameliorate dextran sodium sulfate‐induced ulcerative colitis in rats by regulating Th17/Treg cell balance through PTEN/PI3K/AKT/mTOR axis

BACKGROUND AND AIM: Programmed death‐ligand 1 (PD‐L1) was involved in regulating Th17/Treg cell balance in ulcerative colitis (UC). Extracellular vesicles (EVs) from genetically modified bone marrow mesenchymal stem cells (BMSCs) can serve as a stable delivery system to overexpress PD‐L1. The study...

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Detalles Bibliográficos
Autores principales: He, Hongxia, Chen, Qianyun, Fan, Heng, Leng, Xue yuan, Zhu, Feng, Gao, Fei, Zhou, Qiaoli, Dong, Yalan, Yang, Jia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles ‐ Gastroenterology (Experimental)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10087423/
https://www.ncbi.nlm.nih.gov/pubmed/36044618
http://dx.doi.org/10.1111/jgh.15987

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10087423/
https://www.ncbi.nlm.nih.gov/pubmed/36044618
http://dx.doi.org/10.1111/jgh.15987

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