Activating SIRT1 deacetylates NF-κB p65 to alleviate liver inflammation and fibrosis via inhibiting NLRP3 pathway in macrophages

Background and aims: Macrophages play a critical role in the development of liver diseases. As an NAD(+)-dependent histone deacetylase, SIRT1 inhibits liver inflammation and fibrosis, but the mechanisms are not fully understood. Our aim was to investigate the molecular mechanism of SIRT1 in macropha...

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Detalles Bibliográficos
Autores principales: He, Shuli, Wang, Yaru, Liu, Jinying, Li, Pengju, Luo, Xiaoying, Zhang, Bingyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10087625/
https://www.ncbi.nlm.nih.gov/pubmed/37057212
http://dx.doi.org/10.7150/ijms.77955

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10087625/
https://www.ncbi.nlm.nih.gov/pubmed/37057212
http://dx.doi.org/10.7150/ijms.77955

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