Thymoquinone induces apoptosis in temozolomide‐resistant glioblastoma cells via the p38 mitogen‐activated protein kinase signaling pathway

Temozolomide (TMZ) can cross the blood‐brain barrier (BBB) and deliver methyl groups to the purine (guanine) bases of DNA, leading to mispairing during DNA replication and subsequent cell death. However, increased expression of the repair enzyme methyl guanine methyltransferase (MGMT), which removes...

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Detalles Bibliográficos
Autores principales: Mai, Ai, Ye, Shu‐Wen, Tu, Jia‐Yu, Gao, Jun, Kang, Zhan‐Fang, Yao, Qian‐Ming, Ting, Wei‐Jen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10087852/
https://www.ncbi.nlm.nih.gov/pubmed/36176197
http://dx.doi.org/10.1002/tox.23664

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10087852/
https://www.ncbi.nlm.nih.gov/pubmed/36176197
http://dx.doi.org/10.1002/tox.23664

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