A combined physiologically‐based pharmacokinetic and quantitative systems pharmacology model for modeling amyloid aggregation in Alzheimer's disease

Antibody‐mediated removal of aggregated β‐amyloid (Aβ) is the current, most clinically advanced potential disease‐modifying treatment approach for Alzheimer's disease. We describe a quantitative systems pharmacology (QSP) approach of the dynamics of Aβ monomers, oligomers, protofibrils, and pla...

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Detalles Bibliográficos
Autores principales: Geerts, Hugo, Walker, Mike, Rose, Rachel, Bergeler, Silke, van der Graaf, Piet H., Schuck, Edgar, Koyama, Akihiko, Yasuda, Sanae, Hussein, Ziad, Reyderman, Larisa, Swanson, Chad, Cabal, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088087/
https://www.ncbi.nlm.nih.gov/pubmed/36632701
http://dx.doi.org/10.1002/psp4.12912

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088087/
https://www.ncbi.nlm.nih.gov/pubmed/36632701
http://dx.doi.org/10.1002/psp4.12912

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