Potent dual MAGL/FAAH inhibitor AKU-005 engages endocannabinoids to diminish meningeal nociception implicated in migraine pain

BACKGROUND: Engaging the endocannabinoid system through inhibition of monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH), degrading endocannabinoids (endoCBs) 2-arachidonoylglycerol (2-AG) and anandamide (AEA), was proposed as a promising approach to ameliorate migraine pain. Howev...

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Detalles Bibliográficos
Autores principales: Della Pietra, Adriana, Krivoshein, Georgii, Ivanov, Konstantin, Giniatullina, Raisa, Jyrkkänen, Henna-Kaisa, Leinonen, Ville, Lehtonen, Marko, van den Maagdenberg, Arn M. J. M., Savinainen, Juha, Giniatullin, Rashid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Milan 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088116/
https://www.ncbi.nlm.nih.gov/pubmed/37038131
http://dx.doi.org/10.1186/s10194-023-01568-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088116/
https://www.ncbi.nlm.nih.gov/pubmed/37038131
http://dx.doi.org/10.1186/s10194-023-01568-3

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