Cargando…

Potent dual MAGL/FAAH inhibitor AKU-005 engages endocannabinoids to diminish meningeal nociception implicated in migraine pain

BACKGROUND: Engaging the endocannabinoid system through inhibition of monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH), degrading endocannabinoids (endoCBs) 2-arachidonoylglycerol (2-AG) and anandamide (AEA), was proposed as a promising approach to ameliorate migraine pain. Howev...

Descripción completa

Detalles Bibliográficos
Autores principales:	Della Pietra, Adriana, Krivoshein, Georgii, Ivanov, Konstantin, Giniatullina, Raisa, Jyrkkänen, Henna-Kaisa, Leinonen, Ville, Lehtonen, Marko, van den Maagdenberg, Arn M. J. M., Savinainen, Juha, Giniatullin, Rashid
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Milan 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088116/ https://www.ncbi.nlm.nih.gov/pubmed/37038131 http://dx.doi.org/10.1186/s10194-023-01568-3

Ejemplares similares

Distinct Activity of Endocannabinoid-Hydrolyzing Enzymes MAGL and FAAH in Key Regions of Peripheral and Central Nervous System Implicated in Migraine
por: Della Pietra, Adriana, et al.
Publicado: (2021)

Therapeutic endocannabinoid augmentation for mood and anxiety disorders: comparative profiling of FAAH, MAGL and dual inhibitors
por: Bedse, Gaurav, et al.
Publicado: (2018)

Potential application of endocannabinoid system agents in neuropsychiatric and neurodegenerative diseases—focusing on FAAH/MAGL inhibitors
por: Ren, Si-yu, et al.
Publicado: (2020)

Hexafluoroisopropyl Carbamates as Selective MAGL and Dual MAGL/FAAH Inhibitors: Biochemical and Physicochemical Properties
por: Barth, Maximilian, et al.
Publicado: (2022)

Aku-aku : the secret of Easter Island
por: Heyerdahl, Thor
Publicado: (1960)

The role of the meningeal lymphatic system in local meningeal inflammation and trigeminal nociception
por: Mikhailov, Nikita, et al.
Publicado: (2022)

Activation of Meningeal Afferents Relevant to Trigeminal Headache Pain after Photothrombotic Stroke Lesion: A Pilot Study in Mice
por: Krivoshein, Georgii, et al.
Publicado: (2022)

Protective Effects of Hydrogen Sulfide Against the ATP-Induced Meningeal Nociception
por: Koroleva, Kseniia, et al.
Publicado: (2020)

Dual Inhibition of FAAH and MAGL Counteracts Migraine-like Pain and Behavior in an Animal Model of Migraine
por: Greco, Rosaria, et al.
Publicado: (2021)

The endocannabinoid hydrolase FAAH is an allosteric enzyme
por: Dainese, Enrico, et al.
Publicado: (2020)

Author Correction: The endocannabinoid hydrolase FAAH is an allosteric enzyme
por: Dainese, Enrico, et al.
Publicado: (2020)

Inhibiting Endocannabinoid Hydrolysis as Emerging Analgesic Strategy Targeting a Spectrum of Ion Channels Implicated in Migraine Pain
por: Della Pietra, Adriana, et al.
Publicado: (2022)

Deciphering in silico the Role of Mutated Na(V)1.1 Sodium Channels in Enhancing Trigeminal Nociception in Familial Hemiplegic Migraine Type 3
por: Suleimanova, Alina, et al.
Publicado: (2021)

A polymorphism in the gene of the endocannabinoid-degrading enzyme FAAH (FAAH C385A) is associated with emotional–motivational reactivity
por: Conzelmann, Annette, et al.
Publicado: (2012)

The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors
por: Savinainen, J R, et al.
Publicado: (2012)

Endocannabinoid Regulation of Acute and Protracted Nicotine Withdrawal: Effect of FAAH Inhibition
por: Cippitelli, Andrea, et al.
Publicado: (2011)

The endocannabinoid gene faah2a modulates stress-associated behavior in zebrafish
por: Krug, Randall G., et al.
Publicado: (2018)

Beyond the Canonical Endocannabinoid System. A Screening of PPAR Ligands as FAAH Inhibitors
por: Brunetti, Leonardo, et al.
Publicado: (2020)

FAAH and CNR1 Polymorphisms in the Endocannabinoid System and Alcohol-Related Sleep Quality
por: Soundararajan, Soundarya, et al.
Publicado: (2021)

Potential of Fatty Acid Amide Hydrolase (FAAH), Monoacylglycerol Lipase (MAGL), and Diacylglycerol Lipase (DAGL) Enzymes as Targets for Obesity Treatment: A Narrative Review
por: Matheson, Justin, et al.
Publicado: (2021)

Weak Hypotensive Effect of Chronic Administration of the Dual FAAH/MAGL Inhibitor JZL195 in Spontaneously Hypertensive Rats as Revealed by Area under the Curve Analysis
por: Toczek, Marek, et al.
Publicado: (2023)

Meningeal Mast Cells Contribute to ATP-Induced Nociceptive Firing in Trigeminal Nerve Terminals: Direct and Indirect Purinergic Mechanisms Triggering Migraine Pain
por: Koroleva, Ksenia, et al.
Publicado: (2019)

Migraine-relevant sex-dependent activation of mouse meningeal afferents by TRPM3 agonists
por: Krivoshein, G., et al.
Publicado: (2022)

Differential modulation of nociceptive versus non-nociceptive synapses by endocannabinoids
por: Higgins, Alexandra, et al.
Publicado: (2013)

Ion Channels of Nociception
por: Giniatullin, Rashid
Publicado: (2020)

Correction to: Migraine-relevant sex-dependent activation of mouse meningeal afferents by TRPM3 agonists
por: Krivoshein, G., et al.
Publicado: (2022)

Endocannabinoids Have Opposing Effects On Behavioral Responses To Nociceptive And Non-nociceptive Stimuli
por: Summers, Torrie, et al.
Publicado: (2017)

Draft Genome Sequence of Curtobacterium flaccumfaciens Strain UCD-AKU (Phylum Actinobacteria)
por: Flanagan, Jennifer C., et al.
Publicado: (2013)

New Disulfiram Derivatives as MAGL-Selective Inhibitors
por: Omran, Ziad
Publicado: (2021)

Higher Preimplantation Opioid Doses Associated With Long‐Term Spinal Cord Stimulation Failure in 211 Patients With Failed Back Surgery Syndrome
por: Nissen, Mette, et al.
Publicado: (2020)

Gabapentinoids Associated With Lower Explantation Rate in 203 Patients With Spinal Cord Stimulation for Failed Back Surgery Syndrome
por: Nissen, Mette, et al.
Publicado: (2021)

An endocannabinoid catabolic enzyme FAAH and its paralogs in an early land plant reveal evolutionary and functional relationship with eukaryotic orthologs
por: Haq, Imdadul, et al.
Publicado: (2020)

Upper limb dysfunction and activities in daily living in idiopathic normal pressure hydrocephalus
por: Sirkka, Jani, et al.
Publicado: (2021)

Localization of the cannabinoid CB1 receptor and the 2-AG synthesizing (DAGLα) and degrading (MAGL, FAAH) enzymes in cells expressing the Ca(2+)-binding proteins calbindin, calretinin, and parvalbumin in the adult rat hippocampus
por: Rivera, Patricia, et al.
Publicado: (2014)

Brain structural changes in cannabis dependence: association with MAGL
por: Manza, Peter, et al.
Publicado: (2019)

Editorial: Common and distinct mechanisms of migraine and stroke
por: Giniatullin, Rashid, et al.
Publicado: (2023)

Gender-Specific Mechanism of Synaptic Impairment and Its Prevention by GCSF in a Mouse Model of ALS
por: Naumenko, Nikolay, et al.
Publicado: (2011)

Interaction between NMDA Receptor- and Endocannabinoid-Mediated Modulation of Nociceptive Synapses
por: Yuan, Sharleen, et al.
Publicado: (2019)

FAAH inhibitors in the limelight, but regrettably
por: Mallet, Christophe, et al.
Publicado: (2016)

A potent and selective inhibitor for the modulation of MAGL activity in the neurovasculature
por: Kemble, Alicia M., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_nu8ik4amrl8kgov120cevog7l0