Research progress of engineered mesenchymal stem cells and their derived exosomes and their application in autoimmune/inflammatory diseases

Autoimmune/inflammatory diseases affect many people and are an important cause of global incidence and mortality. Mesenchymal stem cells (MSCs) have low immunogenicity, immune regulation, multidifferentiation and other biological characteristics, play an important role in tissue repair and immune re...

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Autores principales: Zhu, Xueqing, Ma, Dan, Yang, Baoqi, An, Qi, Zhao, Jingwen, Gao, Xinnan, Zhang, Liyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088151/
https://www.ncbi.nlm.nih.gov/pubmed/37038221
http://dx.doi.org/10.1186/s13287-023-03295-7
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author Zhu, Xueqing
Ma, Dan
Yang, Baoqi
An, Qi
Zhao, Jingwen
Gao, Xinnan
Zhang, Liyun
author_facet Zhu, Xueqing
Ma, Dan
Yang, Baoqi
An, Qi
Zhao, Jingwen
Gao, Xinnan
Zhang, Liyun
author_sort Zhu, Xueqing
collection PubMed
description Autoimmune/inflammatory diseases affect many people and are an important cause of global incidence and mortality. Mesenchymal stem cells (MSCs) have low immunogenicity, immune regulation, multidifferentiation and other biological characteristics, play an important role in tissue repair and immune regulation and are widely used in the research and treatment of autoimmune/inflammatory diseases. In addition, MSCs can secrete extracellular vesicles with lipid bilayer structures under resting or activated conditions, including exosomes, microparticles and apoptotic bodies. Among them, exosomes, as the most important component of extracellular vesicles, can function as parent MSCs. Although MSCs and their exosomes have the characteristics of immune regulation and homing, engineering these cells or vesicles through various technical means, such as genetic engineering, surface modification and tissue engineering, can further improve their homing and other congenital characteristics, make them specifically target specific tissues or organs, and improve their therapeutic effect. This article reviews the advanced technology of engineering MSCs or MSC-derived exosomes and its application in some autoimmune/inflammatory diseases by searching the literature published in recent years at home and abroad.
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spelling pubmed-100881512023-04-12 Research progress of engineered mesenchymal stem cells and their derived exosomes and their application in autoimmune/inflammatory diseases Zhu, Xueqing Ma, Dan Yang, Baoqi An, Qi Zhao, Jingwen Gao, Xinnan Zhang, Liyun Stem Cell Res Ther Review Autoimmune/inflammatory diseases affect many people and are an important cause of global incidence and mortality. Mesenchymal stem cells (MSCs) have low immunogenicity, immune regulation, multidifferentiation and other biological characteristics, play an important role in tissue repair and immune regulation and are widely used in the research and treatment of autoimmune/inflammatory diseases. In addition, MSCs can secrete extracellular vesicles with lipid bilayer structures under resting or activated conditions, including exosomes, microparticles and apoptotic bodies. Among them, exosomes, as the most important component of extracellular vesicles, can function as parent MSCs. Although MSCs and their exosomes have the characteristics of immune regulation and homing, engineering these cells or vesicles through various technical means, such as genetic engineering, surface modification and tissue engineering, can further improve their homing and other congenital characteristics, make them specifically target specific tissues or organs, and improve their therapeutic effect. This article reviews the advanced technology of engineering MSCs or MSC-derived exosomes and its application in some autoimmune/inflammatory diseases by searching the literature published in recent years at home and abroad. BioMed Central 2023-04-11 /pmc/articles/PMC10088151/ /pubmed/37038221 http://dx.doi.org/10.1186/s13287-023-03295-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Zhu, Xueqing
Ma, Dan
Yang, Baoqi
An, Qi
Zhao, Jingwen
Gao, Xinnan
Zhang, Liyun
Research progress of engineered mesenchymal stem cells and their derived exosomes and their application in autoimmune/inflammatory diseases
title Research progress of engineered mesenchymal stem cells and their derived exosomes and their application in autoimmune/inflammatory diseases
title_full Research progress of engineered mesenchymal stem cells and their derived exosomes and their application in autoimmune/inflammatory diseases
title_fullStr Research progress of engineered mesenchymal stem cells and their derived exosomes and their application in autoimmune/inflammatory diseases
title_full_unstemmed Research progress of engineered mesenchymal stem cells and their derived exosomes and their application in autoimmune/inflammatory diseases
title_short Research progress of engineered mesenchymal stem cells and their derived exosomes and their application in autoimmune/inflammatory diseases
title_sort research progress of engineered mesenchymal stem cells and their derived exosomes and their application in autoimmune/inflammatory diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088151/
https://www.ncbi.nlm.nih.gov/pubmed/37038221
http://dx.doi.org/10.1186/s13287-023-03295-7
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