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RA-RAR signaling promotes mouse vaginal opening through increasing β-catenin expression and vaginal epithelial cell apoptosis

BACKGROUND: Retinoic acid (RA) plays important role in the maintenance and differentiation of the Müllerian ducts during the embryonic stage via RA receptors (RARs). However, the function and mechanism of RA-RAR signaling in the vaginal opening are unknown. METHOD: We used the Rarα knockout mouse mo...

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Detalles Bibliográficos
Autores principales: Zheng, Nana, Zhang, Wenbo, Zhang, Xiaodan, Li, Biao, Wu, Zhanying, Weng, Yashuang, Wang, Weiyong, Miao, Jingjing, Yang, Jing, Zhang, Meijia, Xia, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088237/
https://www.ncbi.nlm.nih.gov/pubmed/37041518
http://dx.doi.org/10.1186/s12958-023-01084-8