Design, synthesis, biochemical and in silico characterization of novel naphthalene-thiourea conjugates as potential and selective inhibitors of alkaline phosphatase

Naphthalene ring is present in a number of FDA-approved, commercially available medications, including naphyrone, terbinafine, propranolol, naproxen, duloxetine, lasofoxetine, and bedaquiline. By reacting newly obtained 1-naphthoyl isothiocyanate with properly modified anilines, a library of ten nov...

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Detalles Bibliográficos
Autores principales: Saeed, Aamer, Ashraf, Saba, Aziz, Mubashir, Channar, Pervaiz Ali, Ejaz, Syeda Abida, Fayyaz, Ammara, Abbas, Qamar, Alasmary, Fatmah Ali, Karami, Abdulnasser Mahmoud, Tehzeeb, Arfa, Mumtaz, Amara, El-Seedi, Hesham R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088808/
https://www.ncbi.nlm.nih.gov/pubmed/37305207
http://dx.doi.org/10.1007/s00044-023-03051-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088808/
https://www.ncbi.nlm.nih.gov/pubmed/37305207
http://dx.doi.org/10.1007/s00044-023-03051-9

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