Targeting 5-HT(2A) receptors and Kv7 channels in PFC to attenuate chronic neuropathic pain in rats using a spared nerve injury model

Chronic pain remains a disabling disease with limited therapeutic options. Pyramidal neurons in the prefrontal cortex (PFC) express excitatory G(q)-coupled 5-HT(2A) receptors (5-HT(2A)R) and their effector system, the inhibitory Kv7 ion channel. While recent publications show these cells innervate b...

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Detalles Bibliográficos
Autores principales: Vizcarra, Velia S., Barber, Kara R., Franca-Solomon, Gabriela, Majuta, Lisa, Smith, Angela, Langlais, Paul R., Largent-Milnes, Tally M., Vanderah, Todd W., Riegel, Arthur C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088904/
https://www.ncbi.nlm.nih.gov/pubmed/36063980
http://dx.doi.org/10.1016/j.neulet.2022.136864

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088904/
https://www.ncbi.nlm.nih.gov/pubmed/36063980
http://dx.doi.org/10.1016/j.neulet.2022.136864

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