Synthesis, DFT calculations, and anti-proliferative evaluation of pyrimidine and selenadiazolopyrimidine derivatives as dual Topoisomerase II and HSP90 inhibitors

Novel series of aminopyrimidines bearing a biologically active cyclohexenone 3a–f and oxo-selaneylidene moiety 4, besides selenadiazolopyrimidines (5a–e and 7), were synthesised using 5,6-diaminouracils as starting materials. Compound 3a exhibited strong anti-proliferative activity against three cel...

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Detalles Bibliográficos
Autores principales: El-Kalyoubi, Samar, El-Sebaey, Samiha A., Rashad, A. M., AL-Ghulikah, Hanan A., Ghorab, Mostafa M., Elfeky, Sherin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088926/
https://www.ncbi.nlm.nih.gov/pubmed/37036011
http://dx.doi.org/10.1080/14756366.2023.2198163

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088926/
https://www.ncbi.nlm.nih.gov/pubmed/37036011
http://dx.doi.org/10.1080/14756366.2023.2198163

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