Cargando…

Synthesis, DFT calculations, and anti-proliferative evaluation of pyrimidine and selenadiazolopyrimidine derivatives as dual Topoisomerase II and HSP90 inhibitors

Novel series of aminopyrimidines bearing a biologically active cyclohexenone 3a–f and oxo-selaneylidene moiety 4, besides selenadiazolopyrimidines (5a–e and 7), were synthesised using 5,6-diaminouracils as starting materials. Compound 3a exhibited strong anti-proliferative activity against three cel...

Descripción completa

Detalles Bibliográficos
Autores principales:	El-Kalyoubi, Samar, El-Sebaey, Samiha A., Rashad, A. M., AL-Ghulikah, Hanan A., Ghorab, Mostafa M., Elfeky, Sherin M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2023
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088926/ https://www.ncbi.nlm.nih.gov/pubmed/37036011 http://dx.doi.org/10.1080/14756366.2023.2198163

Ejemplares similares

Novel Aminopyrimidine-2,4-diones, 2-Thiopyrimidine-4-ones, and 6-Arylpteridines as Dual-Target Inhibitors of BRD4/PLK1: Design, Synthesis, Cytotoxicity, and Computational Studies
por: El-Kalyoubi, Samar, et al.
Publicado: (2023)

Novel pyrimidine Schiff bases and their selenium-containing nanoparticles as dual inhibitors of CDK1 and tubulin polymerase: design, synthesis, anti-proliferative evaluation, and molecular modelling
por: El-Kalyoubi, Samar, et al.
Publicado: (2023)

Design, synthesis, docking, and anticancer evaluations of new thiazolo[3,2-a] pyrimidines as topoisomerase II inhibitors
por: El-Zoghbi, Mona S., et al.
Publicado: (2023)

New Pyrimidine-5-Carbonitriles as COX-2 Inhibitors: Design, Synthesis, Anticancer Screening, Molecular Docking, and In Silico ADME Profile Studies
por: AL-Ghulikah, Hanan A., et al.
Publicado: (2022)

Synthesis and anticancer evaluation of some novel pyrimido[5,4-e][1,2,4]triazines and pyrazolo[3,4-d]pyrimidine using DMF-DMA as methylating and cyclizing agent
por: El-Kalyoubi, Samar A.
Publicado: (2018)

Synthesis, In Silico Prediction and In Vitro Evaluation of Antitumor Activities of Novel Pyrido[2,3-d]pyrimidine, Xanthine and Lumazine Derivatives
por: El-Kalyoubi, Samar, et al.
Publicado: (2020)

Synthesis, In Silico Prediction and In Vitro Evaluation of Antimicrobial Activity, DFT Calculation and Theoretical Investigation of Novel Xanthines and Uracil Containing Imidazolone Derivatives
por: El-Kalyoubi, Samar, et al.
Publicado: (2021)

Synthesis of pyrido-annelated [1,2,4,5]tetrazines, [1,2,4]triazepine, and [1,2,4,5]tetrazepines for anticancer, DFT, and molecular docking studies
por: Hassan, Aisha Y., et al.
Publicado: (2023)

Design, Synthesis, and Anti-Proliferative Action of Purine/Pteridine-Based Derivatives as Dual Inhibitors of EGFR and BRAF(V600E)
por: El-Kalyoubi, Samar A., et al.
Publicado: (2023)

A Novel Synthesis of Fused Uracils: Indenopyrimidopyridazines, Pyrimidopyridazines, and Pyrazolopyrimidines for Antimicrobial and Antitumor Evalution
por: El-Kalyoubi, Samar, et al.
Publicado: (2016)

Investigation the antioxidant activity of benzo[g]triazoloquinazolines correlated with a DFT study
por: Almehizia, Abdulrahman A., et al.
Publicado: (2019)

Synthesis, X-ray Diffraction, Thermogravimetric and DFT Analyses of Pyrimidine Derivatives
por: Barakat, Assem, et al.
Publicado: (2014)

Synthesis, human topoisomerase IIα inhibitory properties and molecular modeling studies of anti-proliferative curcumin mimics
por: Fawzy, Nehmedo G., et al.
Publicado: (2019)

Correction: El-kalyoubi, S.; et al. Novel 2-Thioxanthine and Dipyrimidopyridine Derivatives: Synthesis and Antimicrobial Activity. Molecules, 2015, 20, 19263--19276
por: El-kalyoubi, Samar, et al.
Publicado: (2018)

Novel 2-Thioxanthine and Dipyrimidopyridine Derivatives: Synthesis and Antimicrobial Activity †
por: El-kalyoubi, Samar, et al.
Publicado: (2015)

A non-proliferative role of pyrimidine metabolism in cancer
por: Siddiqui, Aarif, et al.
Publicado: (2020)

Erratum to: One pot synthesis, antimicrobial and antioxidant activities of fused uracils: pyrimidodiazepines, lumazines, triazolouracil and xanthines
por: El-Kalyoubi, Samar A., et al.
Publicado: (2017)

One pot synthesis, antimicrobial and antioxidant activities of fused uracils: pyrimidodiazepines, lumazines, triazolouracil and xanthines
por: El-Kalyoubi, Samar A., et al.
Publicado: (2017)

1,3,4-Oxadiazole N-Mannich Bases: Synthesis, Antimicrobial, and Anti-Proliferative Activities
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2021)

Structural basis for topoisomerase VI inhibition by the anti-Hsp90 drug radicicol
por: Corbett, Kevin D., et al.
Publicado: (2006)

New benzothieno[2,3-c]pyridines as non-steroidal CYP17 inhibitors: design, synthesis, anticancer screening, apoptosis induction, and in silico ADME profile studies
por: Khalil, Nadia A., et al.
Publicado: (2021)

Design, synthesis, anti-proliferative evaluation, docking, and MD simulation studies of new thieno[2,3-d]pyrimidines targeting VEGFR-2
por: El-Metwally, Souad A., et al.
Publicado: (2023)

Inhibition of Hsp90 acts synergistically with topoisomerase II poisons to increase the apoptotic killing of cells due to an increase in topoisomerase II mediated DNA damage
por: Barker, Catherine R., et al.
Publicado: (2006)

Inhibition of archaeal growth and DNA topoisomerase VI activities by the Hsp90 inhibitor radicicol
por: Gadelle, D., et al.
Publicado: (2005)

Uracil as a Zn-Binding Bioisostere of the Allergic Benzenesulfonamide in the Design of Quinoline–Uracil Hybrids as Anticancer Carbonic Anhydrase Inhibitors
por: El-Kalyoubi, Samar A., et al.
Publicado: (2022)

Facile Synthesis of Some Coumarin Derivatives and Their Cytotoxicity through VEGFR2 and Topoisomerase II Inhibition
por: Gomaa, Mohamed S., et al.
Publicado: (2022)

Design, synthesis, in silico studies, and biological evaluation of novel pyrimidine-5-carbonitrile derivatives as potential anti-proliferative agents, VEGFR-2 inhibitors and apoptotic inducers
por: Saleh, Abdulrahman M., et al.
Publicado: (2023)

Preparation, Crystal Structure, Supramolecular Assembly, and DFT Studies of Two Organic Salts Bearing Pyridine and Pyrimidine
por: Malik, Abida Naseem, et al.
Publicado: (2023)

Investigation of 4-Hydrazinobenzoic Acid Derivatives for Their Antioxidant Activity: In Vitro Screening and DFT Study
por: Abuelizz, Hatem A., et al.
Publicado: (2021)

Design and synthesis of new spirooxindole candidates and their selenium nanoparticles as potential dual Topo I/II inhibitors, DNA intercalators, and apoptotic inducers
por: El-Kalyoubi, Samar, et al.
Publicado: (2023)

Design, synthesis, docking, MD simulations, and anti-proliferative evaluation of thieno[2,3-d]pyrimidine derivatives as new EGFR inhibitors
por: Sobh, Eman A., et al.
Publicado: (2023)

Synthesis of Cyclobutane Analogue 4: Preparation of Purine and Pyrimidine Carbocyclic Nucleoside Derivatives
por: Hasaneen, Noha, et al.
Publicado: (2019)

Inhibition of Erythromycin and Erythromycin-Induced Resistance among Staphylococcus aureus Clinical Isolates
por: Mahfouz, Aya A., et al.
Publicado: (2023)

Optical Absorption Spectra and Electronic Properties of Symmetric and Asymmetric Squaraine Dyes for Use in DSSC Solar Cells: DFT and TD-DFT Studies
por: El-Shishtawy, Reda M., et al.
Publicado: (2016)

Triethylamine-Promoted Oxidative Cyclodimerization of 2H-Azirine-2-carboxylates to Pyrimidine-4,6-dicarboxylates: Experimental and DFT Study
por: Zakharov, Timofei N., et al.
Publicado: (2023)

New [1,2,4]triazolo[4,3-c]quinazolines as intercalative Topo II inhibitors: Design, synthesis, biological evaluation, and in silico studies
por: Gaber, Ahmed A., et al.
Publicado: (2023)

New Indazol-Pyrimidine-Based Derivatives as Selective Anticancer Agents: Design, Synthesis, and In Silico Studies
por: Al-Tuwaijri, Hanaa M., et al.
Publicado: (2023)

Bicyclic 6 + 6 systems: the chemistry of pyrimido[4,5-d]pyrimidines and pyrimido[5,4-d]pyrimidines
por: Monier, M., et al.
Publicado: (2019)

DFT, ADMET and Molecular Docking Investigations for the Antimicrobial Activity of 6,6′-Diamino-1,1′,3,3′-tetramethyl-5,5′-(4-chlorobenzylidene)bis[pyrimidine-2,4(1H,3H)-dione]
por: El-Shamy, Nesreen T., et al.
Publicado: (2022)

Development of Stable Amino-Pyrimidine–Curcumin Analogs: Synthesis, Equilibria in Solution, and Potential Anti-Proliferative Activity
por: Mari, Matteo, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_noc7v4k9ehcuj1up7mivqq3q6u