Structure of the Wnt–Frizzled–LRP6 initiation complex reveals the basis for coreceptor discrimination

Wnt morphogens are critical for embryonic development and tissue regeneration. Canonical Wnts form ternary receptor complexes composed of tissue-specific Frizzled (Fzd) receptors together with the shared LRP5/6 coreceptors to initiate β-catenin signaling. The cryo-EM structure of a ternary initiatio...

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Detalles Bibliográficos
Autores principales: Tsutsumi, Naotaka, Hwang, Sunhee, Waghray, Deepa, Hansen, Simon, Jude, Kevin M., Wang, Nan, Miao, Yi, Glassman, Caleb R., Caveney, Nathanael A., Janda, Claudia Y., Hannoush, Rami N., Garcia, K. Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10089208/
https://www.ncbi.nlm.nih.gov/pubmed/36893265
http://dx.doi.org/10.1073/pnas.2218238120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10089208/
https://www.ncbi.nlm.nih.gov/pubmed/36893265
http://dx.doi.org/10.1073/pnas.2218238120

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